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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Biocatalytic Reduction of Carbonyl Groups

Author(s): Kaoru Nakamura and Tomoko Matsuda

Volume 10, Issue 11, 2006

Page: [1217 - 1246] Pages: 30

DOI: 10.2174/138527206777698020

Price: $65

Abstract

Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.

Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum


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