Abstract
Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.
Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum
Current Organic Chemistry
Title: Biocatalytic Reduction of Carbonyl Groups
Volume: 10 Issue: 11
Author(s): Kaoru Nakamura and Tomoko Matsuda
Affiliation:
Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum
Abstract: Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.
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Cite this article as:
Nakamura Kaoru and Matsuda Tomoko, Biocatalytic Reduction of Carbonyl Groups, Current Organic Chemistry 2006; 10 (11) . https://dx.doi.org/10.2174/138527206777698020
DOI https://dx.doi.org/10.2174/138527206777698020 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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