Combinatorial Library Synthesis of Antioxidant Compounds

Author(s): Stifun Mittoo.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 9 , Issue 6 , 2006

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Abstract:

Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.

Keywords: Leu-Leu-Pro-His-His (LLPHH), propanediol library, trisubstituted indazoles, naphthoquinone, quinone libraries

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2006
Page: [421 - 423]
Pages: 3
DOI: 10.2174/138620706777698490
Price: $58