Abstract
Interleukin (IL)-1 is a pro-inflammatory cytokine and a central mediator in the cytokine network, and is known to control important functions both in the immune system and inflammation. The activity of IL-1 is counter-regulated by its endogenous inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1 and IL-1Ra are produced and secreted by a variety of cells including those responsible for controlling immunity. A recent study indicated that IL-1 and IL-1Ra transcripts were expressed in the vessel wall, suggesting that these cytokines contribute to the development and progression of vascular diseases. In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model.
Keywords: Cytokine, Interleukin-1, occlusive arterial disease, atherosclerosis, lipid metabolism
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Interleukin-1 and Occlusive Arterial Diseases
Volume: 4 Issue: 3
Author(s): Masatoshi Kusuhara, Kikuo Isoda and Fumitaka Ohsuzu
Affiliation:
Keywords: Cytokine, Interleukin-1, occlusive arterial disease, atherosclerosis, lipid metabolism
Abstract: Interleukin (IL)-1 is a pro-inflammatory cytokine and a central mediator in the cytokine network, and is known to control important functions both in the immune system and inflammation. The activity of IL-1 is counter-regulated by its endogenous inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1 and IL-1Ra are produced and secreted by a variety of cells including those responsible for controlling immunity. A recent study indicated that IL-1 and IL-1Ra transcripts were expressed in the vessel wall, suggesting that these cytokines contribute to the development and progression of vascular diseases. In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model.
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Cite this article as:
Kusuhara Masatoshi, Isoda Kikuo and Ohsuzu Fumitaka, Interleukin-1 and Occlusive Arterial Diseases, Cardiovascular & Hematological Agents in Medicinal Chemistry 2006; 4 (3) . https://dx.doi.org/10.2174/187152506777698335
DOI https://dx.doi.org/10.2174/187152506777698335 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
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