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Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Interleukin-1 and Occlusive Arterial Diseases

Author(s): Masatoshi Kusuhara, Kikuo Isoda and Fumitaka Ohsuzu

Volume 4, Issue 3, 2006

Page: [229 - 235] Pages: 7

DOI: 10.2174/187152506777698335

Price: $65

Abstract

Interleukin (IL)-1 is a pro-inflammatory cytokine and a central mediator in the cytokine network, and is known to control important functions both in the immune system and inflammation. The activity of IL-1 is counter-regulated by its endogenous inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1 and IL-1Ra are produced and secreted by a variety of cells including those responsible for controlling immunity. A recent study indicated that IL-1 and IL-1Ra transcripts were expressed in the vessel wall, suggesting that these cytokines contribute to the development and progression of vascular diseases. In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model.

Keywords: Cytokine, Interleukin-1, occlusive arterial disease, atherosclerosis, lipid metabolism


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