Abstract
Interleukin (IL)-1 is a pro-inflammatory cytokine and a central mediator in the cytokine network, and is known to control important functions both in the immune system and inflammation. The activity of IL-1 is counter-regulated by its endogenous inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1 and IL-1Ra are produced and secreted by a variety of cells including those responsible for controlling immunity. A recent study indicated that IL-1 and IL-1Ra transcripts were expressed in the vessel wall, suggesting that these cytokines contribute to the development and progression of vascular diseases. In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model.
Keywords: Cytokine, Interleukin-1, occlusive arterial disease, atherosclerosis, lipid metabolism
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Interleukin-1 and Occlusive Arterial Diseases
Volume: 4 Issue: 3
Author(s): Masatoshi Kusuhara, Kikuo Isoda and Fumitaka Ohsuzu
Affiliation:
Keywords: Cytokine, Interleukin-1, occlusive arterial disease, atherosclerosis, lipid metabolism
Abstract: Interleukin (IL)-1 is a pro-inflammatory cytokine and a central mediator in the cytokine network, and is known to control important functions both in the immune system and inflammation. The activity of IL-1 is counter-regulated by its endogenous inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1 and IL-1Ra are produced and secreted by a variety of cells including those responsible for controlling immunity. A recent study indicated that IL-1 and IL-1Ra transcripts were expressed in the vessel wall, suggesting that these cytokines contribute to the development and progression of vascular diseases. In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model.
Export Options
About this article
Cite this article as:
Kusuhara Masatoshi, Isoda Kikuo and Ohsuzu Fumitaka, Interleukin-1 and Occlusive Arterial Diseases, Cardiovascular & Hematological Agents in Medicinal Chemistry 2006; 4 (3) . https://dx.doi.org/10.2174/187152506777698335
DOI https://dx.doi.org/10.2174/187152506777698335 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs
Current Pharmacogenomics and Personalized Medicine Brain Protection and Cognitive Function: Cocoa Flavonoids as Nutraceuticals
Current Pharmaceutical Design Evidence for Pleiotropic Effects of Statins in Clinical Trials
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Patent Selections:
Recent Patents on Cardiovascular Drug Discovery Biologics in Systemic Sclerosis
Current Pharmaceutical Biotechnology Human Tissue Kallikrein: A New Bullet for the Treatment of Ischemia
Current Pharmaceutical Design The Effect of TNFα-Inhibitors on Cardiovascular Events in Patients with Rheumatoid Arthritis: An Updated Systematic Review of the Literature
Current Rheumatology Reviews Editorial [Hot topic:Vascular Protective Effects of Ezetimibe: Seeking New Therapeutic Possibilities of Ezetimibe in Vascular Disease (Guest Editor: Minako Yamaoka-Tojo)]
Current Vascular Pharmacology Duloxetine in the Treatment of Depression: An Overview
Central Nervous System Agents in Medicinal Chemistry Microvesicles-mediated Cell Communication in Pulmonary Arterial Hypertension
Current Medicinal Chemistry Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer’s Disease: A Meta-Analysis
Current Alzheimer Research Emerging Targets for the Treatment of Dyslipidemia
Current Medicinal Chemistry Lithium and Kidney, 60 Years Later
Current Drug Safety Low-Dose Methotrexate (LD-MTX) in Rheumatology Practice - A Most Widely Misunderstood Drug
Current Rheumatology Reviews ApoA-I Mimetic Peptides as Anti-Inflammatory Agents
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Transductional and Transcriptional Targeting of Adenovirus for Clinical Applications
Current Gene Therapy Targeting α7 Nicotinic Acetylcholine Receptor to Combat Inflammation in Cardio-Cerebral-Vascular Diseases
Current Drug Targets Pleuroparenchymal Fibroelastosis: Its Clinical Characteristics
Current Respiratory Medicine Reviews Patent Selections
Recent Patents on Cardiovascular Drug Discovery TRP Channels in Vascular Disorders
Current Topics in Medicinal Chemistry