Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard


HSV Amplicons: Neuro Applications

Author(s): Carolyn M. Tyler, Charles A. Wuertzer, William J. Bowers, Howard J. Federoff.


Strategies that employ HSV amplicon vectors in the prevention and/or amelioration of pathogenic states afflicting the central nervous system (CNS) have been extensively documented in preclinical disease models. The versatility of the HSV amplicon platform allows for the implementation of therapeutic approaches that require expression of genes exhibiting neuroprotective or neuroplastic activities, or even applications that necessitate the elaboration of antigenspecific immune responses to pathogenic proteins/structures harbored within the CNS. This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders.

Keywords: Neuroprotection, Ischemic Injuries, Creutzfeld-Jacob disease (CJD), Prion Vaccination, Alzheimer, ’, s Disease, CNS inflammation

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Article Details

Year: 2006
Page: [337 - 350]
Pages: 14
DOI: 10.2174/156652306777592045
Price: $58