Delivering Drugs to the Central Nervous System: A Medicinal Chemistry or a Pharmaceutical Technology Issue?

Author(s): Maurizio Ricci, Paolo Blasi, Stefano Giovagnoli, Carlo Rossi.

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 15 , 2006

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Abstract:

This review aims to summarize the non-invasive approaches employed in delivering drugs to the central nervous system which is severely hindered by the presence of the blood-brain barrier (BBB) that limits molecular permeation. Particular attention will be placed on the several available strategies for delivering drugs into the brain, through circumvention of the BBB, in order to critically address the medicinal chemistry and the pharmaceutical technology contributions.

Keywords: Blood-brain barrier, brain targeting, chemical delivery systems, CNS delivery, SLN, pro-drugs, liposomes, polymeric nanoparticles

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Article Details

VOLUME: 13
ISSUE: 15
Year: 2006
Page: [1757 - 1775]
Pages: 19
DOI: 10.2174/092986706777452461
Price: $58

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