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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Delivering Drugs to the Central Nervous System: A Medicinal Chemistry or a Pharmaceutical Technology Issue?

Author(s): Maurizio Ricci, Paolo Blasi, Stefano Giovagnoli and Carlo Rossi

Volume 13, Issue 15, 2006

Page: [1757 - 1775] Pages: 19

DOI: 10.2174/092986706777452461

Price: $65

Abstract

This review aims to summarize the non-invasive approaches employed in delivering drugs to the central nervous system which is severely hindered by the presence of the blood-brain barrier (BBB) that limits molecular permeation. Particular attention will be placed on the several available strategies for delivering drugs into the brain, through circumvention of the BBB, in order to critically address the medicinal chemistry and the pharmaceutical technology contributions.

Keywords: Blood-brain barrier, brain targeting, chemical delivery systems, CNS delivery, SLN, pro-drugs, liposomes, polymeric nanoparticles


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