The Vasculature as a Target in the Treatment of Pulmonary Emphysema

Title: The Vasculature as a Target in the Treatment of Pulmonary Emphysema

Volume: 7 Issue: 6

Author(s): H. A. Golpon and N. F. Voelkel

Affiliation:

Keywords: Emphysema, Vasculature, Apoptosis, Oxidative Stress, VEGF

Abstract: Pulmonary emphysema, a major component of chronic obstructive pulmonary diseases, is a highly prevalent progressive tissue-destructive disease, with no effective treatments. The interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible progression of the disease. Recent investigations have underlined the importance of the lung vasculature in the pathobiology of chronic obstructive pulmonary diseases offering new therapeutic strategies. This review will focus on the pulmonary microvessels as a target in the treatment of pulmonary emphysema.

Cite this article as:

Golpon A. H. and Voelkel F. N., The Vasculature as a Target in the Treatment of Pulmonary Emphysema, Current Drug Targets 2006; 7 (6) . https://dx.doi.org/10.2174/138945006777435335