Novel Concepts of Statin Therapy for Cardiovascular Risk Reduction in Hypertension

Author(s): George I. Varughese , Jeetesh V. Patel , Gregory Y.H. Lip , Chetan Varma .

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 13 , 2006

Abstract:

Hypertension is associated with an increase in cardiovascular events. Pathophysiological mechanisms of this include endothelial damage / dysfunction, inflammatory activation, insulin resistance, platelet activation and alterations in the coagulation cascade leading to a prothrombotic state. Dyslipidaemia acts synergistically with hypertension in increasing cardiovascular risk. HMG CoA reductase inhibitors (statins) are lipid-lowering drugs and more recently have been shown to have a significant pleiotropic effect on endothelial function, inflammation, platelet activation and coagulation. Statins affect the whole pathophysiology of atherogenesis from deposition to plaque rupture and thrombogenesis because of its pleiotropic effects. Therefore it is intuitive that statins may be of benefit in hypertensive patients with conventionally normal lipid levels by preventing the pathological effects of hypertension. There is an increasing clinical evidence base for statins use in patients with hypertension. In this article, the novel pleiotropic and conventional mechanisms of statins, and clinical data of statin therapy in patients with hypertension are reviewed.

Keywords: Endothelial dysfunction, platelets, Hypercholesterolemia, pleiotropic effect, dyslipidemia, lipoprotein, HMG CoA reductase

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Article Details

VOLUME: 12
ISSUE: 13
Year: 2006
Page: [1593 - 1609]
Pages: 17
DOI: 10.2174/138161206776843304
Price: $58

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