Advance in Antitumor Agents Targeting Glutathione-S-Transferase

Author(s): Guisen Zhao , Xiaobing Wang .

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 12 , 2006

Abstract:

Glutathione-S-transferases (GSTs; EC 2.5.1.18), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). As GSTs are overexpressed in some malignant tumors, GSTs is a promising therapeutic target. This article reviews the progress in the development of GSTs inhibitors and GSTs activated prodrugs.

Keywords: Glutathione-S-transferases, Antitumor agents, Drug-resistance, GST inhibitors, Prodrugs, Apoptosis

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Article Details

VOLUME: 13
ISSUE: 12
Year: 2006
Page: [1461 - 1471]
Pages: 11
DOI: 10.2174/092986706776872934
Price: $58

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