A Computational View of COX-2 Inhibition

Author(s): Philippe Chavatte, Amaury Farce.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 6 , Issue 3 , 2006

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Selective inhibition of COX-2 provided a new class of anti-inflammatory, analgesic and antipyretic drugs with significantly reduced side effects and could also be an important strategy for preventing or treating a number of cancers. This review illustrates the molecular modeling methods used for the knowledge of the molecular mechanism of inhibition as well as for the design of selective compounds.

Keywords: COX-1 enzyme, Diarylheterocycles, COX-2 isoenzymes, nimesulide, QSAR studies, Neural Networks

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Article Details

Year: 2006
Page: [239 - 249]
Pages: 11
DOI: 10.2174/187152006776930909
Price: $58

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