Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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The Use of Nimesulide and Its Analogues in Cancer Chemoprevention

Author(s): Jean-Francois Renard, Fabien Julemont, Xavier d. Leval, Bernard Pirotte.

Abstract:

Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to be cyclooxygenase (COX) inhibitors, have been reported to exert anti-proliferative and pro-apoptotic effects on a variety of cancer cells. Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention. The present review focuses on the state of the art in cancer research developed with COX-2 preferential/selective inhibitors belonging to the family of N-arylmethanesulfonamides, in particular nimesulide and NS-398.

Keywords: Nimesulide, NS-398, cancer chemoprevention, NSAIDs, cyclooxygenase inhibitors, anti-proliferative, proapoptotic, N-arylmethanesulfonamides

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2006
Page: [233 - 237]
Pages: 5
DOI: 10.2174/187152006776930855
Price: $58