Abstract
PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.
Keywords: Analgesic, anti-inflammatory agents, inflammation, inhibitors, 2-oxoamide, pain, phospholipase A2, trifluoromethyl ketone
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2
Volume: 5 Issue: 2
Author(s): Victoria Magrioti and George Kokotos
Affiliation:
Keywords: Analgesic, anti-inflammatory agents, inflammation, inhibitors, 2-oxoamide, pain, phospholipase A2, trifluoromethyl ketone
Abstract: PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.
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Cite this article as:
Magrioti Victoria and Kokotos George, Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (2) . https://dx.doi.org/10.2174/187152306776872451
DOI https://dx.doi.org/10.2174/187152306776872451 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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