Sphingolipids in Anticancer Therapy

Author(s): Jose M. Padron.

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 7 , 2006

Submit Manuscript
Submit Proposal

Abstract:

Sphingolipids constitute a broad class of compounds with many biological functions. The sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and produce cell cycle arrest, whereas sphingosine-1-phosphate promotes cellular growth and differentiation. Herein, the effects of sphingolipids and their analogs on diverse signaling pathways implicated in the apoptotic process are highlighted. The relatively simple chemical structure of these compounds has led to several strategies for their total synthesis. Those methods have contributed to the development and biological study of several analogs that present diverse degree of modification from the original structure. This article catalogues many of the recently developed synthetic analogs that act on diverse aspects of sphingolipid metabolism. A description of known enzyme inhibitors of the sphigolipids pathway is also given. Finally, diverse new sphingolipid-like antitumor agents isolated from marine sources are presented. This contribution opens the way for future development of new sphingolipid analogs that might be useful in cancer chemotherapy.

Keywords: Sphingolipid analogs, sphingosine, ceramide, apoptosis, signal transduction, anticancer drugs, structure-activity relationships, drug design

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 7
Year: 2006
Page: [755 - 770]
Pages: 16
DOI: 10.2174/092986706776055553
Price: $58

Article Metrics

PDF: 2