Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy

Author(s): George W. Kabalka, Min-Liang Yao.


The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.

Keywords: isotopes, linear energy transfer (LET), 4-Dihydroxyborylphenylalanine, water-solubilizing functional group, melanoma, Bucherer-Strecker reaction

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Article Details

Year: 2006
Page: [111 - 125]
Pages: 15
DOI: 10.2174/187152006776119144
Price: $58