Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents

Author(s): V. I. Bregadze, I. B. Sivaev, S. A. Glazun.

Abstract:

The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.

Keywords: Boron, carborane, borane, boron neutron capture therapy, radionuclides, anticancer drugs

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2006
Page: [75 - 109]
Pages: 35
DOI: 10.2174/187152006776119180
Price: $58