Abstract
Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptins biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
Keywords: leptin receptor, CRH-knockout, lymphocytes, DTH reaction, pro-inflammatory mediators, Septic Shock
Current Medicinal Chemistry
Title: A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update
Volume: 13 Issue: 4
Author(s): W. Waelput, P. Brouckaert, D. Broekaert and J. Tavernier
Affiliation:
Keywords: leptin receptor, CRH-knockout, lymphocytes, DTH reaction, pro-inflammatory mediators, Septic Shock
Abstract: Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptins biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
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Cite this article as:
Waelput W., Brouckaert P., Broekaert D. and Tavernier J., A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update, Current Medicinal Chemistry 2006; 13 (4) . https://dx.doi.org/10.2174/092986706775527929
DOI https://dx.doi.org/10.2174/092986706775527929 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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