Oxidative Folding of Conotoxins in Immobilized Systems

Author(s): B. R. Green, G. Bulaj.

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 1 , 2006

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Abstract:

We tested two alternative oxidation strategies to produce conotoxins α-GI and μ-PIIIA. The peptides were either reversibly immobilized on a solid support and then oxidized, or the immobilized disulfide reagent (CLEAR-OX™) was used to oxidize the peptides. Both strategies appeared more efficient at higher peptide concentrations, consistent with pseudo-dilution effects.

Keywords: Conotoxins, Oxidative folding, Immobilized, CLEAR-OXTM

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2006
Page: [67 - 70]
Pages: 4
DOI: 10.2174/092986606774502162

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