Recent Advances in Flavivirus Antiviral Drug Discovery and Vaccine Development
Debashish Ray and Pei-Yong Shi
Affiliation: 120 New Scotland Avenue,Wadsworth Center, New York State Department of Health, Albany, NewYork 12208, USA;
Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.
Keywords: Flavivirus, vaccine, antiviral, drug discovery, RNA virus, inhibitor
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