Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel
Arnold-Heller-Straße 3
Kiel, D-24105
Germany

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Recent Advances in Flavivirus Antiviral Drug Discovery and Vaccine Development

Author(s): Debashish Ray and Pei-Yong Shi

Affiliation: 120 New Scotland Avenue,Wadsworth Center, New York State Department of Health, Albany, NewYork 12208, USA;

Keywords: Flavivirus, vaccine, antiviral, drug discovery, RNA virus, inhibitor

Abstract:

Many flaviviruses, including yellow fever virus, dengue virus, Japanese encephalitis virus, tick-borne encephalitis virus, and West Nile virus, are globally important human pathogens. Despite an emergence and resurgence of flavivirus-mediated disease, specific therapies are not yet available; however, significant progress has been made toward the prevention and treatment of flavivirus infections. In this article we review recent advances made in the areas of (i) flavivirus vaccine development, and (ii) antiflavivirus drug discovery reported in literature and patents, and highlight strategies used in these investigations.

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Article Details

VOLUME: 1
ISSUE: 1
Page: [45 - 55]
Pages: 11
DOI: 10.2174/157489106775244055