Immunological Mechanisms of Specific Allergen Immunotherapy

Author(s): Carsten B. Schmidt-Weber, Kurt Blaser.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 5 , Issue 1 , 2006

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Abstract:

Allergy is an immunological disorder, which is driven by uncontrolled allergen-activated T cell subsets, leading to immediate type hypersensitivity against otherwise harmless environmental allergens. These allergens are tolerated by healthy individuals as well as by patients, who successfully underwent allergen-specific immunotherapy (SIT). The successful SIT is characterized by the induction of T cell unresponsiveness against the given allergen. Regulatory T cells (Tregs), which are installed or enhanced by SIT and govern the activity of potentially pro-allergic effector T cells, mediate this unresponsiveness. The current article reviews the mechanisms underlying the balance of these cell populations along with suppressive mechanisms of SIT, which may serve as future drug targets.

Keywords: inflammatory factors, allergy, antigen-presenting cells, pathogen-associated molecular patterns (PAMPs), phosphatidylinositol, –, 3-phosphatase (PI3K)

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2006
Page: [15 - 21]
Pages: 7
DOI: 10.2174/187152806775269321

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