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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 12
ISSUE: 1
DOI: 10.2174/138161206775193208









Is There a Role for Cytokine Based Therapies in Fibromyalgia

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Author(s): Daniel J. Wallace
Pages 17-22 (6)
Abstract:
Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.
Keywords:
neuromuscular pain, hypothalamic-pituitary-adrenal (HPA) axis, non-inflammatory process, thyrotropin, lymphocyte proliferation responses, Chronic Fatigue Syndrome, rheumatology
Affiliation:
8737 Beverly Blvd, Suite 203,Los Angeles, CA 90048,USA.