Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE


The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik

Affiliation: Department of Pathology, University of California, San Francisco, CA 94143, USA.


Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [99 - 109]
Pages: 11
DOI: 10.2174/156652406775574587