The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins
Scott A. Oakes, Stephen S. Lin and Michael C. Bassik
Affiliation: Department of Pathology, University of California, San Francisco, CA 94143, USA.
Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
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