The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins
Scott A. Oakes, Stephen S. Lin and Michael C. Bassik
Pages 99-109 (11)
Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression
Department of Pathology, University of California, San Francisco, CA 94143, USA.