Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik

Affiliation: Department of Pathology, University of California, San Francisco, CA 94143, USA.

Abstract:

Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression

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Article Details

VOLUME: 6
ISSUE: 1
Page: [99 - 109]
Pages: 11
DOI: 10.2174/156652406775574587