Tumor Control by Manipulation of the Human Anti-Apoptotic Survivin Gene

Author(s): Zakir Khan, Pratiksha Bhadouria, Radha Gupta, Prakash S. Bisen.

Journal Name:Current Cancer Therapy Reviews

Volume 2 , Issue 1 , 2006

Abstract:

Survivin is a relatively unique member of the inhibitor of apoptosis protein (IAP) family. It contains a single baculovirus IAP repeat (BIR) domain. It is involved in the control of cell cycle and inhibition of apoptosis. Survivin is of interest because it is specifically up-regulated in cancer cells and completely down-regulated and undetectable in normal adult tissues. Thus, survivin has proved to be a promising therapeutic target for normal anti-cancer therapy. Survivin protects the fast dividing tumor cells against default apoptosis to facilitate aberrant mitosis. Down-regulation of survivin with multiple approaches, suppress tumor progression and induce apoptosis on its own or in combination with chemotherapy and radiotherapy.

Keywords: Survivin, IAPs, Apoptosis, Caspases, Ribozyme, p53

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2006
Page: [73 - 79]
Pages: 7
DOI: 10.2174/157339406777592113