Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer
Eliana P. Araujo,
Jose B. Carvalheira,
Licio A. Velloso.
Several growth-promoting signaling pathways have tight molecular connections with metabolicrelated signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energyacquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.
Keywords: protein kinase B, protein remodeling, Akt Activation, phosphotyrosine binding (PTB), CCI-779, Antisense oligonucleotides
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