Use of PI Index in Computer-Aided Designing of Bioactive Compounds

Title: Use of PI Index in Computer-Aided Designing of Bioactive Compounds

Volume: 2 Issue: 1

Author(s): Padmakar V. Khadikar, Mircea V. Diudea, Jyoti Singh, Peter E. John, Anjalee Shrivastva, Shalini Singh, Sneha Karmarkar, Meenakshi Lakhwani and Purnima Thakur

Affiliation:

Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity

Abstract: In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.

Cite this article as:

Khadikar V. Padmakar, Diudea V. Mircea, Singh Jyoti, John E. Peter, Shrivastva Anjalee, Singh Shalini, Karmarkar Sneha, Lakhwani Meenakshi and Thakur Purnima, Use of PI Index in Computer-Aided Designing of Bioactive Compounds, Current Bioactive Compounds 2006; 2 (1) . https://dx.doi.org/10.2174/1573407210602010019