Use of PI Index in Computer-Aided Designing of Bioactive Compounds

Author(s): Padmakar V. Khadikar , Mircea V. Diudea , Jyoti Singh , Peter E. John , Anjalee Shrivastva , Shalini Singh , Sneha Karmarkar , Meenakshi Lakhwani , Purnima Thakur .

Journal Name: Current Bioactive Compounds

Volume 2 , Issue 1 , 2006

Become EABM
Become Reviewer

Abstract:

In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.

Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 2
ISSUE: 1
Year: 2006
Page: [19 - 56]
Pages: 38
DOI: 10.2174/1573407210602010019

Article Metrics

PDF: 8