Use of PI Index in Computer-Aided Designing of Bioactive Compounds
Padmakar V. Khadikar,
Mircea V. Diudea,
Peter E. John,
In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.
Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity
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