Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy

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Use of PI Index in Computer-Aided Designing of Bioactive Compounds

Author(s): Padmakar V. Khadikar, Mircea V. Diudea, Jyoti Singh, Peter E. John, Anjalee Shrivastva, Shalini Singh, Sneha Karmarkar, Meenakshi Lakhwani, Purnima Thakur.

Abstract:

In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.

Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2006
Page: [19 - 56]
Pages: 38
DOI: 10.2174/1573407210602010019