Synthetic Ion Channels As Novel Antimicrobial Agents

Author(s): Zachary T. Cusumano , George W. Gokel .

Journal Name: Current Bioactive Compounds

Volume 2 , Issue 1 , 2006

Become EABM
Become Reviewer


Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.

Keywords: synthetic ion transporters, hydraphiles, minimum bactericidal concentration (MBC), alpha-helical conformation, ANTIBIOTICS

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [13 - 18]
Pages: 6
DOI: 10.2174/1573407210602010013

Article Metrics

PDF: 10