Synthetic Ion Channels As Novel Antimicrobial Agents

Zachary   T.   Cusumano; George   W.   Gokel

Abstract

Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.

Keywords: synthetic ion transporters, hydraphiles, minimum bactericidal concentration (MBC), alpha-helical conformation, ANTIBIOTICS

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Current Bioactive Compounds

Title: Synthetic Ion Channels As Novel Antimicrobial Agents

Volume: 2 Issue: 1

Author(s): Zachary T. Cusumano and George W. Gokel

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Keywords: synthetic ion transporters, hydraphiles, minimum bactericidal concentration (MBC), alpha-helical conformation, ANTIBIOTICS

Abstract: Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.

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Cusumano T. Zachary and Gokel W. George, Synthetic Ion Channels As Novel Antimicrobial Agents, Current Bioactive Compounds 2006; 2 (1) . https://dx.doi.org/10.2174/1573407210602010013