Single Cell Proteomics: Challenge for Current Analytical Science

Author(s): Bo Xu, Wei Du, Bi-Feng Liu, Qingming Luo.

Journal Name:Current Analytical Chemistry

Volume 2 , Issue 1 , 2006


At present, proteomics that promises deep understanding of genomic functions is developing rapidly. Proteomics at single cell level represents new challenges that greatly call for technique innovation in current analytical chemistry. In this mini-review, the concept of single cell proteomics (SCP) is clarified. Recent advancement on strategy and methodology of SCP is reviewed, with emphasis on micro-separation technique improvement such as ultra-thin layer gel electrophoresis, multidimensional micro liquid chromatography and capillary electrophoresis, and microfluidic chip as well. Future development on SCP is also suggested.

Keywords: Single cell proteomics, Protein separation, Chromatography, Capillary electrophoresis, Microfluidic chip, Review

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Article Details

Year: 2006
Page: [67 - 76]
Pages: 10
DOI: 10.2174/157341106775197402