Abstract
Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.
Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)
Anti-Cancer Agents in Medicinal Chemistry
Title: Understanding Apoptosis in Terms of QSAR
Volume: 6 Issue: 1
Author(s): Rajeshwar P. Verma
Affiliation:
Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)
Abstract: Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.
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Cite this article as:
Verma P. Rajeshwar, Understanding Apoptosis in Terms of QSAR, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/187152006774755528
DOI https://dx.doi.org/10.2174/187152006774755528 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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