Understanding Apoptosis in Terms of QSAR
Rajeshwar P. Verma.
Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.
Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)
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