The Pharmaceutical Scientist Guide to Solution Kinetic Models Mathematical Description and Applications

Thermodynamics and kinetics (i.e., chemical interactions) are extremely important concepts for pharmaceutical scientists to understand since the “drug selection process”, that is, the process ...
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Other Inhibition Enzyme Reactions [ Substrate Inhibition Enzyme Reactions ( Section XVII)

Pp. 357-379 (23)

Gary W. Caldwell

Abstract

Inhibition by Multiple Substrates Binding to the Enzyme

In cases where a high concentration of substrate is used, the substrate itself may cause inhibition. This type of inhibition can be identified when the rate declines instead of approaching the maximum velocity. The form of the rate equations will depend on the type of inhibition. Consider the reversible binding reaction (XVII.1) where two substrate molecules bind to the enzyme....

Affiliation:

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.