Manipulation of Host-Cell Apoptosis during Infection with Toxoplasma gondii
Pp. 109-122 (14)
Apoptosis play a crucial role in the interaction between hosts and parasites. Apoptotic response includes innate
and adaptive immunities to restrict intracellular parasite replication and regulatory functions to modulate host immune
responses. The obligate intracellular protozoan Toxoplasma gondii extensively modifies apoptosis of its own host cell or
of uninfected bystander cells. Upon infection with T. gondii, apoptosis is triggered in T lymphocytes, macrophages and
other leukocytes, thereby suppressing immune responses against the parasite. On the other hand, T. gondii inhibits hostcell
apoptosis by direct or indirect mechanisms in the infected cells to facilitate parasite survival. The dual activity of T.
gondii to both promote and inhibit apoptosis requires tight regulation to stabilize host and parasite interaction and
establish toxoplasmosis. Here, molecular mechanisms behind the inhibition or induction of apoptosis by T. gondii
infection and their pathogenesis are focused on.
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan