Immune Response to Parasitic Infections

Volume: 1

Protozoa

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

This Ebook provides an interesting and up-to-date overview of Parasite Immunology in terms of a survival battle between hosts and parasites, describing firstly how parasites interact with different B ...
[view complete introduction]

US $
30

*(Excluding Mailing and Handling)



Progress Toward the Development of a Plasmodium Vivax Malaria Vaccine

Pp. 43-54 (12)

Socrates Herrera and Myriam Arevalo-Herrera

Abstract

It is currently estimated that a total of 2.6 billion people live at a permanent risk of suffering malaria infection worldwide, and that 80-300 million experience Plasmodium vivax infections every year mostly in areas outside Africa. The increasing P. vivax drug resistance and recent reports of severe and lethal cases, the relapsing parasite behavior and the existence of Plasmodium spp. co-infections must prompt more investment and greater efforts for the development of a P. vivax vaccine. Because of funding shortage and technical difficulties, currently there are only two P. vivax vaccine candidates being tested in clinical trials and few others are being assessed in preclinical studies which contrast with the numerous P. falciparum vaccine candidates under evaluation. However, the recent availability of the P. vivax genome and ongoing proteomic analysis are likely to accelerate P. vivax vaccine development. Additionally, recent development of human sporozoite-challenge models would contribute to move clinical development forward and to identify mechanisms of immunity.

Affiliation:

Centro Internacional de Vacunas, AA 26020, Cali, Colombia and Immunology Institute, Universidad del Valle, AA 25574, Cali, Colombia