Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

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This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of ...
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Transporterization: A Tool for Drug Delivery to the Central Nervous System

Pp. 213-228 (16)

Gabor Orgovan and Bela Noszal

Abstract

Drug delivery to the central nervous system (CNS) has long been recognised as an enormous task, due to the physiological gate-keeping function of the blood-brain barrier (BBB). With the development of molecular biology, the function and properties of the BBB are better understood. In this review, transporterization, a promising method for drug delivery by endogenous proteins, is discussed, and a survey of the reported results is presented.

Affiliation:

Semmelweis University, Department of Pharmaceutical Chemistry.