Solubility, Delivery and ADME Problems of Drugs and Drug Candidates

Author(s): Karoly Tihanyi and Monika Vastag

Indexed in: Chemical Abstracts, Scopus, Book Citation Index, Science Edition, BIOSIS

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This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of ...
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Foreword  promotion: free to download

Pp. i

Olavi Pelkonen



Preface  promotion: free to download

Pp. ii-iii (2)

Károly Tihanyi



Contributors  promotion: free to download

Pp. iv-v (2)

K. Tihanyi and M. Vastag



Recent Advances in ADME Predictions

Pp. 3-32 (30)

Laszlo Molnar and Gyorgy M. Keseru


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Solubility as a Challenge in Drug Research and Development

Pp. 52-67 (16)

Attila Sandor Halász


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Preclinical Formulation in Early Drug Research

Pp. 68-85 (18)

Ottilia Balazs


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Intestinal Absorption and Models of Penetration

Pp. 86-101 (16)

Eva Hellinger and Monika Vastag


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Membrane and Dye Efflux Assays to Detect and Characterize the Interaction of Drugs with ABC Transporters

Pp. 102-116 (15)

Eniko Ioja, Zoltan Nagy, Viktoria Juhasz, Judit Janossy, Krisztina Heredi-Szabo and Peter Krajcsi


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Induction and Inhibition of Drug Metabolizing Enzymes

Pp. 117-143 (27)

Karoly Tihanyi


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Drug Transport and the Blood-Brain Barrier

Pp. 144-165 (22)

Maria A. Deli


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Tools for Modelling Blood-Brain Barrier Penetrability

Pp. 166-188 (23)

Szilvia Veszelka, Agnes Kittel and Maria A. Deli


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Cell-Penetrating Peptides and Protein Transduction Domains in Drug Delivery

Pp. 189-212 (24)

Erno Duda and Tamas Letoha


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Transporterization: A Tool for Drug Delivery to the Central Nervous System

Pp. 213-228 (16)

Gabor Orgovan and Bela Noszal


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Subject Index  promotion: free to download

Pp. 229-232 (4)

K. Tihanyi and M. Vastag