Controversies in Neuro-Oncology

Avastin and Malignant Gliomas

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Neuro-oncology is an embryonic field of cancer research with a number of clinical trials in progress. However, the prognosis on neuro-oncologic patients has remained poor. Moreover, several small ...
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Inhibitors of VEGF Signaling Pathways in Glioblastoma: Is the Evidence Sufficient for Widespread Use? A European Perspective

Pp. 140-143 (4)

M. J. van den Bent

Abstract

VEGF Signaling Pathways in Glioblastoma: Is the Evidence Sufficient for Widespread Use? A European Perspective

First uncontrolled trials suggest significant activity of bevacizumab in recurrent glioblastoma. However, many questions still remain unresolved, in particular in view of the occurrence of pseudo-responses, the development of gliomatosis cerebri, the unclear impact on survival, and the high costs associated with this treatment. Further studies need to focus the early identification of responders, better combination regimen, and on the assessment of survival benefit. The widespread use of bevacizumab prior to registration may actually become an obstacle for the answering of some of these questions.

Affiliation:

Department Neuro-Oncology, Daniel den Hoed Cancer Center/Erasmus University Hospital Rotterdam, Rotterdam, The Netherlands.