Frontiers in Medicinal Chemistry

Volume: 4

Indexed in: BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in ...
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Protein Tyrosine Phosphatases and Their Inhibitors

Pp. 371-423 (53)

Yogesh S. Tingare, Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Keywords:

Cellular signaling, diseases, PTPs, SAR, inhibitors, therapeutics/drugs

Affiliation:

Department of Chemistry, National Central University, Chung Li, Taiwan 32054, ROC.