Frontiers in Medicinal Chemistry

Volume: 4

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“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in ...
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Medicinal Plant Extracts and Molecules as the Source of New Anti-Snake Venom Drugs

Pp. 309-346 (38)

Andreimar M. Soares, Silvana Marcussi, Renata S. Fernandes, Danilo L. Menaldo, Tassia R. Costa, Miriam V. Lourenco, Ana Helena Januario and Paulo S. Pereira

Abstract

The use of plant extracts and isolated chemical compounds as antidotes against snake venoms is a common practice in places where a prompt access to serum therapy is lacking. Although there are a number of reports on plants from different geographical areas that are able to neutralize snake venoms, only a few chemical compounds have been isolated and identified as active components. In reviewing this area of research, it can be concluded that many plants recorded in popular use as anti-snake venoms may display antidotal properties due to the great number of active compounds they contain. However, it is also clear that not all claims of antidote effects towards snake venoms are warranted. In addition, biotechnological application of these inhibitors, as helpful alternative or supplemental treatments serum therapy, and also as important models for synthesis of new drugs of medical interest, needs to be better oriented and scientifically explored.

Keywords:

Medicinal plants, antiophidian plants, anti-snake venom, natural inhibitors, ethnopharmacological studies, structural approaches

Affiliation:

Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, FCFRP, Universidade de Sao Paulo, USP, Ribeirao Preto-SP, Brazil.