Frontiers in Medicinal Chemistry

Volume: 4

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“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in ...
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Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

Pp. 285-308 (24)

Zhengming Guo, Suryanarayana Vangapandu, Robert W. Sindelar, Larry A. Walker and Robert D. Sindelar

Abstract

Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.

Keywords:

Quassinoids, semi-synthesis, total synthesis, biological activities, SAR, antileukemic and antimalarial activities

Affiliation:

Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, B. C., V6T1Z3, Canada.