Frontiers in Medicinal Chemistry

Volume: 3

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry ...
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Trends in Hit-to-Lead: An Update

Pp. 653-673 (21)

Benoit Deprez and Rebecca Deprez-Poulain

Abstract

The goal of this paper is to review the variety of approaches used to improve lead generation, in terms of cost, time and risk management. Our analysis shows that successful lead generation requires not only an accurate definition of the needs (to define the most relevant assay protocols and readouts), but most of all a good hit as a starting point. It also appears that teams where techniques and knowledge are combined, are more successful in that difficult game.

Keywords:

Hit-to-lead (H2L), optimisation, High Throughput Screening (HTS), parallel synthesis, library design, Structure-activity relationships (SAR), Structure-property relationships (SPR), functional assay, druggability, rational drug design

Affiliation:

Institut Pasteur de Lille, Universite de Lille 2, Faculte des Sciences Pharmaceutiques et Biologiques, 3 rue du Pr Calmette, F-59006 Lille Cedex, France.