Frontiers in Medicinal Chemistry

Volume: 3

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry ...
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An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression

Pp. 435-454 (20)

O. M. Zack Howard and Carole L. Galligan

Abstract

The contribution of small molecular weight chemoattractant cytokines (chemokines) and their receptors in the trafficking of tumor, immune and vascular cells pertaining to the development and progression of cancer has begun to be investigated. The current literature indicates that interactions between the immune network, angiogenic and cell survival cascades are important for the trafficking and progression of human cancer and that chemokines and chemokine receptors play a central role in these complex inter-related pathways. Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists.

Affiliation:

National Cancer Institute (NCI), Center for Cancer Research (CCR), Laboratory of Molecular Immunoregulation (LMI), NCI-Frederick, P.O. Box B, Frederick, MD 21702, USA.