Integral Tissue Participation in Carcinogenesis
Pp. 73-74 (2)
Lawrence M. Agius
Simple delineation of the evolutionary dynamics of neoplastic growth in contrast with a host
of associated biologic events in neoplastic infiltration of stroma and adjacent tissues or the metastatic
spread of the tumor cells, bring into prominent profile the diversity of architectural reconstitutive
identity of neoplasms in a manner constant with a great diversity of genetic mutability. In this sense,
the further progression of injury as genotoxicity proves an underlying demonstrative step in its own
right in formulating the characterizations of the carcinogenetic steps in malignant transformation of
cells and tissues.
carcinogenesis, genotoxicity, evolutionary.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.