Theory in the Pathophysiology of Carcinogenesis

Indexed in: Scopus, EBSCO.

This e-book explains the essential role of angiogenesis in the progression and spread of the neoplasm, including the mechanics of initial carcinogenesis in promoting malignant transformation. The ...
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Integral Tissue Participation in Carcinogenesis

Pp. 73-74 (2)

Lawrence M. Agius


Simple delineation of the evolutionary dynamics of neoplastic growth in contrast with a host of associated biologic events in neoplastic infiltration of stroma and adjacent tissues or the metastatic spread of the tumor cells, bring into prominent profile the diversity of architectural reconstitutive identity of neoplasms in a manner constant with a great diversity of genetic mutability. In this sense, the further progression of injury as genotoxicity proves an underlying demonstrative step in its own right in formulating the characterizations of the carcinogenetic steps in malignant transformation of cells and tissues.


carcinogenesis, genotoxicity, evolutionary.


Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.