Transition Dynamics of In Situ Carcinogenesis
Pp. 49-51 (3)
Lawrence M. Agius
Transition dynamics conclusively determines the malignant transformation steps that
chiefly characterize the objective development of invasive tumor attributes within foci of pre-existing
carcinoma in situ, as seen particularly with primary breast neoplasia. The conceptual definition of in
situ neoplasia is linked with the developmental dynamics of a field effect in carcinogenesis. It is
significant that there is no direct relative involvement in frequency of invasive attributes as considered
in terms of the quantification of the in situ change initially present.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.