Peritoneal Implantation as Integral Non-Sequential Events in Susceptibility to Ovarian Carcinogenesis
Pp. 44-48 (5)
Lawrence M. Agius
Aberrant, convergent pathways of sequential and non-sequential nature characterize the
malignant transformation process as integral to the primary spread of metastatic lesions in cases such
as ovarian carcinoma. One might further demonstrate a series of influential consequences that arises as
phenomenal attributes of such integral neogenesis of the primary carcinomatous focus on the ovary
with the development of focally specific susceptibility of peritoneal foci for implant evolution. Hence,
it is the further formulation of events as dynamics of such focal peritoneal susceptibility that contrasts
with a traditionally recognized system of metastatic implantation in the genesis of peritoneal lesions in
cases of malignant ovarian carcinoma. It is, in fact, the biology of neogenesis of the primary ovarian
neoplasm that participates in the formulation of final non-sequential systems of susceptibility
implicating peritoneal attributes in terms of the pathobiology of primary carcinogenesis of the ovarian
germinal epithelium and of developmental systems of infiltration of the underlying ovarian stroma and
peritoneal, ovarian, carcinogenesis, implantation.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.