Hypothetical Simple Transfer Mechanics as Malignant Transformation and as Infiltrative and Metastatic Neoplastic Potential
Pp. 22-27 (6)
Lawrence M. Agius
Interventional reconstitution of events in carcinogenesis resembles the conceptual hierarchical
organization of events leading to perceptible aggregation of the neoplastic cells around foci of tumor
necrosis, individual neurons and also perivascularly. The dimensions of such aggregation constitute a real
reference point in the further elucidation of genesis in terms of events that project as propagation and as
anti-apoptosis of these same neoplastic cells. In terms, therefore, that permit the emergence of abnormal
homeostatic control mechanisms in cellular constitutional events there might further develop an overall
permissive environment based on further constitutional change. Transfer of unitary elements such as
genetic material would implicate a revolutionary change in bearing with such elements as the
developmental status and maintenance of events that promote and further amplify infiltration of stroma
and metastatic spread via vascular involvement in a systemic fashion.
transfer, transformation, neoplastic potential, genetic.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.