Theory in the Pathophysiology of Carcinogenesis

Indexed in: Scopus, EBSCO.

This e-book explains the essential role of angiogenesis in the progression and spread of the neoplasm, including the mechanics of initial carcinogenesis in promoting malignant transformation. The ...
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Increments in Cellular Proliferation as Defining Index in Dysplasia and Malignant Transformation in Ulcerative Colitis--Amplifying Attributes of Neogenesis

Pp. 16-21 (6)

Lawrence M. Agius


Contrasting influence exerted by a chronicity of the acute inflammatory reactivity affecting the colorectal mucosa in ulcerative colitis induces a progression in dysplasia as permissive conditioning of the cellular microenvironment. Inducible representative models would allow the emergence of a series of consequential pathways as identifiable profiles that project as carcinogenesis. It is in terms of relatively simple dimensional increase in proliferative cellular activity that epithelial cell dysplasia further promotes malignant transformation in the relative absence of corrective or reparative gene expression systems. The increased potentiality for malignant change is symptomatic of the progressiveness towards definable loss of fidelity of constitutive pathways that both specifically and non-specifically contribute to pathobiology of carcinogenetic pathways as overlapping incomplete profiles of preneoplastic and paraneoplastic integrative systems of reproducibility.


proliferation, transformation, preneoplastic, paraneoplastic.


Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.