Contrasting Profiles of High Grade Gliomas as Malignant Transformation of the Individual Neoplastic Astrocyte
Pp. 9-15 (7)
Lawrenc M. Agius
Dimensions of further incremental progression in infiltration of the central nervous system
by high grade glioma are symptomatic of the overall implications of the individual astrocyte that
undergoes a malignant change in the first instance. Such malignant transformation is faithfully
incorporated within dimensional context of an infiltrative tumor front that encompasses further
malignant transformation in its own right. It is the significant role of several aggregates of neoplastic
astrocytes that allows for the amplification of the injury beyond the development of infiltrative
attributes and as a consequential contrast of attributes between genotype and phenotype
characterization. The individual malignant astrocyte is indeed a specific form of malignancy that
incorporates the dimensions of an infiltrative front evidenced by whole aggregates of such individual
malignant astrocytes. It is in terms of ongoing amplification that the developmental dimensions of
injury are translated into onset and progression of the malignant transformation process, and as further
evidenced by field effect in carcinogenesis.
Hence, infiltrativeness by neoplastic astrocytes is both individually manifested and also an aggregate
phenomenon in subsequent reconstitution of the injury at cellular and tissue level of operative
gliomas, individual astrocyte, infiltration, injury.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.