Regionality of Anti-Apoptosis Predetermines Pro-Neoplastic Biology of Cell Proliferation as Induced Metastatic Spread
Pp. 3-8 (6)
Lawrence M. Agius
Pathways of induced realization constitute strictly regional conglomeration of antiapoptosis
effect in terms of the injury to the cell genome and of the preselectivity of further
characterized biology of systemic projection as metastatic spread. One might consider it significant in
terms of the genotoxicity of malignant transformation as it is a step-wise recharacterization of the
metastatic cascade. It is particularly significant to consider injury as an agonist effect of unique and
far-reaching effect and in terms of sequential amplification and reconstitution, beyond simple
dimensions of the given individual neoplastic cell. One might therefore consider the impact of biologic
agonists beyond simple developmental origin of stem cells or as etiologic dissemination of potential
local and systemic spread effect arising as genomic toxicity. Carcinogenesis hence constitutes a
mirrored model in the constitutive re-characterization of unique features in genomic serial
transformations beyond simple enumeration of toxic agents or of pathogenesis of the individuality of
the malignant cell in transformation.
anti-apoptosis, stem cells, metastasis, proliferation.
Department of Pathology, University of Malta Medical School Mater Dei Hospital, MALTA EUROPE.