NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers
Pp. 184-213 (30)
Hoang Nam Nhat and Tran Thi Hong
We present a concise review on current advances in the field of application of Nuclear
Magnetic Resonance (NMR) in Structure-Activity Relationship (SAR) study of nanostructure
drugs, particularly of paclitaxel-loaded nanocarriers. A short introduction of NMR to nonspecialists
is also included. The review is separated into two parts, the first discusses in broader
context the concepts and potentials of drug-loaded nanocarriers as the modern tumour active
targeting systems and the second focuses on the paclitaxel-loaded nanocarriers, especially on
conformations and tubulin-binding forms of paclitaxel. The application of nanoscience in
pharmaceutical researches explodes very fast with many anti-tumour drugs recently been approved
to the market. We survey only the important and latest issues in this field.
NMR, paclitaxel, nanocarrier, drug delivery, structure, cancer.
Department of Technical Physics and Nanotechnology, UET, Vietnam National University Hanoi, 144 Xuan Thuy, Cau Giay, Hanoi, Vietnam.