Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy

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Drug discovery is still a process which involves screening of a large number of chemical compounds against a defined biological target. However, this approach is now being gradually replaced by more ...
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NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers

Pp. 184-213 (30)

Hoang Nam Nhat and Tran Thi Hong


We present a concise review on current advances in the field of application of Nuclear Magnetic Resonance (NMR) in Structure-Activity Relationship (SAR) study of nanostructure drugs, particularly of paclitaxel-loaded nanocarriers. A short introduction of NMR to nonspecialists is also included. The review is separated into two parts, the first discusses in broader context the concepts and potentials of drug-loaded nanocarriers as the modern tumour active targeting systems and the second focuses on the paclitaxel-loaded nanocarriers, especially on conformations and tubulin-binding forms of paclitaxel. The application of nanoscience in pharmaceutical researches explodes very fast with many anti-tumour drugs recently been approved to the market. We survey only the important and latest issues in this field.


NMR, paclitaxel, nanocarrier, drug delivery, structure, cancer.


Department of Technical Physics and Nanotechnology, UET, Vietnam National University Hanoi, 144 Xuan Thuy, Cau Giay, Hanoi, Vietnam.