Frontiers in Medicinal Chemistry

Volume: 2

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry ...
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Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

Pp. 357-369 (13)

Ben Shen, Wen Liu and Koichi Nonaka

Abstract

Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

This review gives a brief account on the current status of enediyne biosynthesis and the prospective of applying combinatorial biosynthesis methods to the enediyne system for novel analog production. Methods for cloning enedlyne biosynthetic gene clusters are first reviewed. A unified paradigm for enediyne biosynthesis, characterized with (a) the enediyne PKS, (b) the enediyne PKS accessory enzymes, and (c) tailoring enzymes, is then presented. Strategies and tools for novel enediyne analog production by combinatorial biosynthesis are finally discussed. The results set the stage to decipher the molecular mechanism for enediyne biosynthesis and lay the foundation to engineer novel enediynes by combinatorial biosynthesis for future endeavor.

Keywords:

Biosynthesis, C-1027, calicheamicin, combinatorial biosynthesis, enediyne, polyketide synthase

Affiliation:

Department of Chemistry, University of Wisconsin, Madison, WI 53705, USA.